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Thesis

Statistical challenges in the detection of mutation and variation using high throughput sequencing

Abstract:

The aim of this thesis is to obtain a better understanding of mutation rates within as well as between the genomes of humans and chimpanzees using data generated by high throughput sequencers. I will start with a review of the field and an overview of the technologies and protocols used to generate and analyse high throughput sequencing data. I apply some of the discussed techniques to show that there is evidence of a selective advantage of pathogenic de novo mutations in the Fibrobl...

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Research group:
Professor Gil McVean
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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