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Journal article

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.

Abstract:

Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS). Acquired GATA1 mutations are present in both TAM and ML-DS. Current definitions of TAM specify neither the percentage of blasts nor the role of GATA1 mutation analysis. To define TAM, we prospectively analyzed clinical findings, blood counts and smears, and GATA1 mutation status in 200 DS neonates. All DS neonates had multiple blo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1182/blood-2013-07-515148

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Imperial College London More from this funder
National Institute of Health Research More from this funder
Kay Kendall Leukaemia Fund More from this funder
Medical Research Council More from this funder
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Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
122
Issue:
24
Pages:
3908-3917
Publication date:
2013-12-01
Acceptance date:
2013-08-26
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
429236

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