Thesis icon

Thesis

Cellular target engagement and selectivity profiling of small molecules for mechanism-of-action studies

Abstract:

A high-quality chemical probe should possess the qualities of being highly specific, potent, and selective against off-target interactions, in order to enable target validation. By contrast, low-quality compounds, which display properties of promiscuity, reactivity and instability can in turn be misleading: such compounds, referred to as Pan-Assay Interference Compounds (PAINS) need to be removed from screening libraries. Target engagement and proteomic studies can often detect undesirable...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Russell Group
Oxford college:
New College
Role:
Author
ORCID:
0000-0001-9151-4485

Contributors

Sub department:
Target Discovery Institute
Research group:
Huber Group
Role:
Supervisor
ORCID:
0000-0002-1103-5300
Sub department:
Organic Chemistry
Role:
Supervisor
Sub department:
Pharmacology
Role:
Examiner
Role:
Examiner
More from this funder
Programme:
Systems Approaches to Biomedical Sciences CDT is supported by funding from the Engineering and Physical Sciences Research Council (EPSRC) and the Medical Research Council (MRC), grant number EP/L016044/1
Funding agency for:
Stefaniak, J
Grant:
EP/L016044/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP