Thesis icon

Thesis

A method for the identification of biological pathways

Abstract:

Plenty of gene variants have been associated with disease, indicating widespread genetic heterogeneity, which leaves the molecular basis of complex diseases unclear. However, it is widely postulated that the products of genes whose mutations are implicated in the same disease function together in the same biological pathways and it is the disruption of these pathways that underlies the disease. Such pathways are not well defined and their identification could help elucidate disease mechanisms...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Cross College
Role:
Author

Contributors

Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:e7079080-a814-431a-badd-35080f5a2825
Local pid:
ora:12514
Deposit date:
2016-07-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP