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A method for the identification of biological pathways

Abstract:

Plenty of gene variants have been associated with disease, indicating widespread genetic heterogeneity, which leaves the molecular basis of complex diseases unclear. However, it is widely postulated that the products of genes whose mutations are implicated in the same disease function together in the same biological pathways and it is the disruption of these pathways that underlies the disease. Such pathways are not well defined and their identification could help elucidate disease mechanisms...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:e7079080-a814-431a-badd-35080f5a2825
Local pid:
ora:12514

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