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Thesis

Evaluation of the Immunological Mechanisms Induced by Mycobacteria and the Potential Effect this may have on Immunity Induced by Tuberculosis Vaccines

Abstract:

The efficacy of Bacille-Calmette Guerin (BCG) vaccination in protection against pulmonary tuberculosis (TB) is highly variable between populations. One possible explanation is increased exposure of certain populations to non-tuberculous mycobacteria (NTM). Given the variable efficacy of BCG an improved vaccine against TB is required. The novel TB vaccine MVA85A has shown promising results, however, the immunogenicity of the vaccine is reduced when it is administered in the Expanded Program...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
The Jenner Institute
Oxford college:
Jesus College
Role:
Author
More by this author
Division:
MSD
Department:
NDM
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2012-02-10
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e7f1890e-577e-4346-b7fa-7ae810aa1be4
Local pid:
ora:6743
Deposit date:
2013-03-08

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