Journal article
Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
- Abstract:
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Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism. Here we use an iterative, discovery-based proteomic approach to show that following opioid administration, peroxiredoxin 6 (PRDX6) is recruited to the opioid receptor complex by c-Jun N-terminal kinase (JNK) phosphorylation. PRDX6 activation generates reactive oxygen species via NADPH ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.4MB)
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- Publisher copy:
- 10.1038/s41467-017-00791-2
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Issue:
- 1
- Pages:
- 743
- Publication date:
- 2017-09-29
- Acceptance date:
- 2017-07-27
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Pmid:
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28963507
- Source identifiers:
-
734461
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:734461
- UUID:
-
uuid:e7f5c768-a8e9-4e04-999a-e5dfe2b18cd5
- Local pid:
- pubs:734461
- Deposit date:
- 2018-09-06
Terms of use
- Copyright holder:
- *Copyright holder name ("et al" as required)*
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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