Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Journal article

Mutations within cytotoxic T lymphocyte (CTL) epitopes impair T cell recognition, but escape mutations arising in flanking regions that alter antigen processing have not been defined in natural human infections. In human histocompatibility leukocyte antigen (HLA)-B57+ HIV-infected persons, immune selection pressure leads to a mutation from alanine to proline at Gag residue 146 immediately preceding the NH2 terminus of a dominant HLA-B57-restricted epitope, ISPRTLNAW. Although N-extended wild-...

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Authors: Draenert, R; Le Gall, S; Pfafferott, K; Leslie, A; Chetty, P

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 199
• Issue: 7
• Pages: 905-915
• Publication date: 2004-04-01
• DOI: 10.1084/jem.20031982
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Amino Acid Sequence; Epitopes; Mutation; HIV Infections; Base Sequence; T-Lymphocytes, Cytotoxic; Sequence Homology, Amino Acid; HIV-1; Genetic Variation; Clone Cells; DNA, Viral; Gene Products, gag; Humans; Antigen Presentation; HLA-B Antigens; Molecular Sequence Data; Alleles; HIV Antigens