Book section icon

Book section

A review of the human Sigma-1 Receptor structure

Abstract:

The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an exce...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1007/978-3-319-50174-1_3

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-8204-7608
Publisher:
Springer Verlag Publisher's website
Volume:
964
Pages:
15-29
Series:
Advances in Experimental Medicine and Biology
Host title:
Advances in experimental medicine and biology
Publication date:
2017-03-18
Acceptance date:
2016-05-01
DOI:
ISSN:
0065-2598
Pmid:
28315262
Source identifiers:
686926
ISBN:
9783319501727
Language:
English
Keywords:
Pubs id:
pubs:686926
UUID:
uuid:e8c97507-8d82-4e5d-b80a-5476f2ea6a38
Local pid:
pubs:686926
Deposit date:
2018-10-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP