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Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T

Abstract:

Phosphorus magnetic resonance spectroscopy (31P-MRS) has previously demonstrated decreased energy reserves in the form of phosphocreatine to adenosine-tri-phosphate ratio (PCr/ATP) in the hearts of patients with type 2 diabetes (T2DM). Recent 31P-MRS techniques using 7T systems, e.g. long mixing time stimulated echo acquisition mode (STEAM), allow deeper insight into cardiac metabolism through assessment of inorganic phosphate (Pi) content and myocardial pH, which play pivotal roles in energy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0269957

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-2567-3642
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
17
Issue:
6
Article number:
e0269957
Publication date:
2022-06-16
Acceptance date:
2022-06-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
1264068
Local pid:
pubs:1264068
Deposit date:
2022-06-17

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