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Immunization with different formulations of Mycobacterium tuberculosis antigen 85A induces immune responses with different specificity and protective efficacy

Abstract:

To test the relative efficacy of CD4 and CD8T cells in mediating protective immunity to Mycobacterium tuberculosis (Mtb), we compared three immunization regimes designed to induce preferentially each subset. BALB/c mice were immunized intranasally (i.n.) or parenterally with antigen 85A either in a recombinant Adenoviral vector (Ad85A), as recombinant protein (r85A) or as a set of overlapping 15mer peptides (p85A). For the first time we show that i.n. immunization with overlapping 85A synthet...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2013.07.040

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-4869-5118
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
31
Issue:
41
Pages:
4624-4631
Publication date:
2013-07-27
Acceptance date:
2013-07-16
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pmid:
23896422
Source identifiers:
416296

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