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A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus

Abstract:

The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. To better understand the molecular basis for immune recognition, we raised a class of neutralizing monoclonal antibodies (nAbs) against RVFV Gn, which exhibited protective efficacy in a mouse infection model. Structural characterization revealed that these nAbs were directed to the membrane-distal domain of RVFV Gn a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.12.001

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
BDI-NDM
Role:
Author
ORCID:
0000-0001-8538-4995
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
13
Pages:
3750-3758
Publication date:
2018-12-26
Acceptance date:
2018-11-29
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
30590046
Source identifiers:
954582
Language:
English
Keywords:
Pubs id:
pubs:954582
UUID:
uuid:e92e894b-4bf5-4b11-91d0-ad85c0658ae1
Local pid:
pubs:954582
Deposit date:
2019-01-16

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