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Thesis

Biochemical studies of the cohesin complex

Abstract:

The accurate inheritance of genetic material depends upon the establishment and maintenance of sister chromatid cohesion. Replicated chromosomes are topologically encircled by the large, tripartite protein complex cohesin, allowing bi-orientation in mitosis. To entrap and reversibly dissociate from DNA, the annular complex structure must be disrupted at either the hinge domain between Smc1 and Smc3, or the interfaces created by the kleisin subunit Scc1 bridging the two ABC-like ATPase doma...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof Kim Nasmyth
Oxford college:
Merton College
Role:
Author
More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:e9a77a9c-40a5-466d-a894-c7fefeddef52
Local pid:
ora:8616
Deposit date:
2014-06-13

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