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In vitro, in silico and in vivo studies of the structure and conformational dynamics of DNA Polymerase I

Abstract:

DNA polymerases are a family of molecular machines involved in high-fidelity DNA replication and repair, of which DNA polymerase I (Pol) is one the best-characterized members. Pol is a strand-displacing polymerase responsible for Okazaki fragment synthesis and base-excision repair in bacteria; it consists of three protein domains, which harbour its 5’-3' polymerase, 3’-5’ exonuclease and 5’ endonuclease activities.

In the first part of the thesis, we use a combination of single-m...

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:ea317d58-00f7-4fc4-b71b-866b4becf0f7
Deposit date:
2016-04-27

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