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Molecular epidemiology of HIV-1 subtype B reveals heterogeneous transmission risk: Implications for intervention and control

Abstract:

Background

The impact of HIV pre-exposure prophylaxis (PrEP) depends on infections averted by protecting vulnerable individuals as well as infections averted by preventing transmission by those who would have been infected if not receiving PrEP. Analysis of HIV phylogenies reveals risk factors for transmission, which we examine as potential criteria for allocating PrEP.

Methods

We analyzed 6912 HIV-1 partial pol sequences from men who have sex with men (MSM) in th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiy044

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Role:
Author
ORCID:
0000-0001-6268-8937
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UK Health Protection Research Units in Modeling Methodology and Sexually Transmitted Infections More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
217
Issue:
10
Pages:
1522-1529
Publication date:
2018-02-26
Acceptance date:
2018-01-22
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
29506269
Source identifiers:
828589
Language:
English
Keywords:
Pubs id:
pubs:828589
UUID:
uuid:ea53e3c0-f4ac-4316-a6b1-8c491bce14a9
Local pid:
pubs:828589
Deposit date:
2018-09-11

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