Journal article
Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
- Abstract:
-
Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains unclear whether saposins can facilitate loading of endogenous iNKT cell agonists in the periphery during inflammatory responses. In addition, it is unclear whether saposins, in addition to loading, ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1310050110
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 49
- Pages:
- E4753-E4761
- Publication date:
- 2013-12-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
439788
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:439788
- UUID:
-
uuid:ea7677ef-a55e-48dd-86fb-6e7b1586bf59
- Local pid:
- pubs:439788
- Deposit date:
- 2013-12-12
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- Copyright date:
- 2013
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