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Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Abstract:

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains unclear whether saposins can facilitate loading of endogenous iNKT cell agonists in the periphery during inflammatory responses. In addition, it is unclear whether saposins, in addition to loading, ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1310050110

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
49
Pages:
E4753-E4761
Publication date:
2013-12-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
439788
Language:
English
Keywords:
Pubs id:
pubs:439788
UUID:
uuid:ea7677ef-a55e-48dd-86fb-6e7b1586bf59
Local pid:
pubs:439788
Deposit date:
2013-12-12

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