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Thesis

Mathematical modelling of cell population dynamics in the colonic crypt with application to colorectal cancer

Abstract:

Colorectal cancer has the third highest mortality and incidence rates of all cancers worldwide, but the prognosis for long-term survival is good if diagnosed early. It is a well-characterised disease, and is initiated in colonic crypts which line the colon wall. The aim of this thesis is to use mathematical modelling to describe the heavily regulated cell renewal cycle in the crypt to determine the key features of the system kinetics, and help to explain the initiation of tumourigenesis. The...

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Research group:
Centre for Mathematical Biology
Oxford college:
Trinity College
Role:
Author

Contributors

Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
More from this funder
Funding agency for:
Johnston, M
Grant:
EP/P500397/1
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:eb1daf53-203c-4ed5-a8af-ab261a61a88c
Local pid:
ora:2797
Deposit date:
2009-05-19

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