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Journal article

The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-mobilizing intracellular messenger and is linked to a variety of stimuli and cell surface receptors. However, the enzyme responsible for endogenous NAADP synthesis in vivo is unknown, and it has been proposed that another enzyme differing from ADP-ribosyl cyclase family members may exist. The ecto-enzyme CD38, involved in many functions as diverse as cell proliferation and social behavior, represents an important ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.125864

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Journal:
Journal of biological chemistry
Volume:
285
Issue:
49
Pages:
38251-38259
Publication date:
2010-12-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
106429
Language:
English
Keywords:
Pubs id:
pubs:106429
UUID:
uuid:eb36fef9-0d70-4590-80df-ae8138dd3c57
Local pid:
pubs:106429
Deposit date:
2012-12-19

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