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Thesis

Bioinformatical and experimental analysis of gene expression regulation through RNAi and alternative polyadenylation

Abstract:

Polyadenylation signals in yeast are not very well defined and are believed to be largely degenerate. Here, we present a computational and experimental genome-wide analysis of polyadenylation signals in Schizosaccharomyces pombe (S. pombe), identifying the canonical AATAAA motif as the most frequent and functional signal. RNA-Seq data from cells grown under various physiological conditions were used to map 3’UTRs, which classify as commonly heterogenic. We have shown that many gen...

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Oxford college:
Keble College
Role:
Author

Contributors

Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Division:
MPLS
Department:
Mathematical Institute
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:eba14f91-7c12-4530-84ca-90ddd75fee58
Local pid:
ora:11385
Deposit date:
2015-05-07

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