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Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity

Abstract:
Background and Aims Oxidative stress plays a key role in the development of metabolic complications associated with obesity, including insulin resistance and the most common chronic liver disease worldwide, nonalcoholic fatty liver disease. We have recently discovered that the microRNA miR-144 regulates protein levels of the master mediator of the antioxidant response, nuclear factor erythroid 2-related factor 2 (NRF2). On miR-144 silencing, the expression of NRF2 target gene... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1053/j.gastro.2021.08.030

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Italian Association for Cancer Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Gastroenterology Journal website
Volume:
161
Issue:
6
Pages:
1982-1997.E11
Publication date:
2021-08-21
Acceptance date:
2021-08-15
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Pmid:
34425095
Language:
English
Keywords:
Pubs id:
1192247
Local pid:
pubs:1192247
Deposit date:
2021-10-27

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