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Thesis

Mechanisms of immunoglobulin deactivation by Streptococcus pyogenes

Abstract:

The bacteria Streptococcus pyogenes produces a multitude of proteins which interact with and alter the functions of the host immune system. Two such proteins, Endoglycosidase S (EndoS) and Immunoglobulin G-degrading enzyme from S. pyogenes (IdeS) are able to specifically alter the effector functions of immunoglobulin G (IgG). EndoS is a glycoside hydrolase which removes the conserved N-linked glycan from IgG Fc whereas IdeS is a cysteine protease that cleaves the e...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Glycobiology Institute
Oxford college:
Linacre College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Dixon, E
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Funding agency for:
Dixon, E
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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