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Journal article

Variation in structural location and amino acid conservation of functional sites in protein domain families

Abstract:

Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods for the prediction of functional sites are of immense value. Most available methods are based on a set of homologous sequences and structural or evolutionary information, and assume that functional sites are more conserved than the average. In the analysis presented here, we have investigated the conservation of loc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2105-6-210

Authors


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Institution:
University of Würzburg
Department:
Department of Bioinformatics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
University of Würzburg
Department:
Department of Bioinformatics
Role:
Author
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Funding agency for:
Pils, B
Grant:
BO-1099/5-2
Publisher:
BioMed Central
Journal:
BMC Bioinformatics Journal website
Volume:
6
Article number:
210
Publication date:
2005-01-01
DOI:
ISSN:
1471-2105
Language:
English
Subjects:
UUID:
uuid:ed0a1189-d699-4839-b227-c49308b43385
Local pid:
ora:2285
Deposit date:
2008-09-04

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