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Thesis

Regulation of human vascular redox state in obesity and insulin resistance

Abstract:

Insulin resistance (IR) and dysfunctional adipose tissue (AT) secretome are believed to mediate the mechanistic links between metabolic and vascular disease. However, the mechanistic details of the interactions between vascular IR, AT-derived products and vascular disease phenotypes in humans are poorly understood. In the first part of my thesis, I attempted to characterise downstream vascular insulin signalling in patients with atherosclerosis and how this could be modified to regulate va...

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Division:
MSD
Department:
Cardiovascular Medicine
Role:
Author

Contributors

Department:
Cardiovascular Medicine
Role:
Supervisor
Department:
Cardiovascular Medicine
Role:
Supervisor
Sanofi Aventis Deutschland GmbH More from this funder
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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