Thesis
Fabrication of an aptamer-functionalised silica nanoparticle construct and its separation by magnetic capture-hybridisation
- Abstract:
-
Nanoparticles produced with surfaces functionalised by highly specific molecular tags are able to target aberrant cells and detect or eliminate them without causing damage to surrounding healthy tissues. Single-stranded DNA (ssDNA) and RNA which fold to form secondary or tertiary structures, termed aptamers, represent a new class of such molecular tags. The nanoparticles, in turn, may carry therapeutic payload or luminescent entities which enable elimination or visualisation of targeted ce...
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Authors
Contributors
+ Darton, R
Division:
MPLS
Department:
Engineering Science
Role:
Supervisor
+ Lubansky, A
Division:
MPLS
Department:
Engineering Science
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:ee1d5b05-f1d0-4336-8831-e54a3daf556a
- Local pid:
- ora:8483
- Deposit date:
- 2014-05-28
Terms of use
- Copyright holder:
- Bulsiewicz, A
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
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