Journal article
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
- Abstract:
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Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10(-8)), implicating gene...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 490.0KB)
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(Version of record, pdf, 1.0MB)
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- Publisher copy:
- 10.1038/ncomms15539
Authors
Funding
+ Medical Research Council
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Funding agency for:
Rahmioglu, N
Grant:
MR/K011480/1
+ Wellcome Trust
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Funding agency for:
Morris, AP
Grant:
Senior Research Fellowship WT098017
WT084766/Z/08/Z;Case-ControlConsortium076113
085475
+ National Health and Medical Research Council of Australia
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Grant:
241,944,339,462,389,927,389,875,389,891,389,892,389,938,443,036,442,915,442,981,496,610,496,739,552,485,552,498,1,026,033
1,050,208
Novo Nordisk Foundation
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 15539
- Publication date:
- 2017-05-24
- Acceptance date:
- 2017-04-07
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:697781
- UUID:
-
uuid:ee51cefe-b4ae-4aa0-89e7-1e89f22d35f0
- Local pid:
- pubs:697781
- Source identifiers:
-
697781
- Deposit date:
- 2017-06-26
Terms of use
- Copyright holder:
- Sapkota et al
- Copyright date:
- 2017
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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