Thesis
Function, phenotype and development of human CD161+CD8 T cells
- Abstract:
-
Tc17 cells and the semi-invariant human mucosal associated invariant T (MAIT) cells are important CD8+ tissue-homing cell populations. Both are characterized by high expression of CD161 (++) and type-17 differentiation, yet their origins and relationships remain poorly defined. By transcriptional and functional analyses it is demonstrated that a pool of polyclonal, pre-committed type-17 CD161++CD8αβ+ T cells exists in cord blood, from which a prominent MAIT cell (TCR Vα7.2+/Vβ2 or 13.2) popul...
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Authors
Contributors
+ Klenerman, P
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Barnes, E
Division:
MSD
Department:
NDM
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:ee5d63dd-5197-492d-af1f-775123444cf9
- Local pid:
- ora:6284
- Deposit date:
- 2012-06-11
Terms of use
- Copyright holder:
- Lucy Jane Walker
- Copyright date:
- 2012
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