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Thesis

The emergence and early fate decisions of stem and progenitor cells in the haematopoietic system

Abstract:

The alternative road map describes the separation of lympho-myeloid and myeloid-megakaryocyte-erythroid (myeloid-Mk-E) lineages as the earliest haematopoietic commitment event. However, a number of aspects of this lineage restriction process remain poorly understood. Herein this work identified a lympho-myeloid restricted progenitor in the embryo, which resembles the adult LMPP, and demonstrated that lymphoid lineage restriction is initiated prior to definitive haematopoiesis, much earlier...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
Haematopoietic Stem Cell Laboratory
Oxford college:
Wolfson College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
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Funding agency for:
Lutteropp, M
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:eef3e876-bde2-4114-8ac2-bf0c87492a55
Local pid:
ora:7070
Deposit date:
2013-07-22

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