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Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response

Abstract:

Psoriasis is a complex inflammatory skin disease affecting ∼3% of the population worldwide. Although type I interferons (IFN-I) are thought to be involved in its pathogenesis, the details of this relationship remain elusive. Here we show that in a murine model of imiquimod-driven psoriatic skin inflammation, Foxp3+ regulatory T cells (T reg cells) control inflammation severity by restraining IFN-I. Depletion of T reg cells induces IFN-I and IFN-stimulated gene expression, and leads to accumul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20172094

Authors


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Role:
Author
ORCID:
0000-0003-3608-064X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
ORCID:
0000-0002-5523-6673
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Funding agency for:
Stockenhuber, A
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Funding agency for:
Powrie, F
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
215
Issue:
8
Pages:
1987-1998
Publication date:
2018-07-06
Acceptance date:
2018-06-11
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pmid:
29980582
Source identifiers:
868030
Language:
English
Pubs id:
pubs:868030
UUID:
uuid:ef1944f2-9d49-4d68-8f04-4c188787b388
Local pid:
pubs:868030
Deposit date:
2018-07-16

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