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Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa

Abstract:

Hepatitis B virus (HBV) DNA viral loads (VL) show wide variation between individuals with chronic hepatitis B (CHB) infection, and are used to determine treatment eligibility. There are few refined descriptions of VL distribution in CHB, and limited understanding of the biology that underpins these patterns. We set out to describe the VL distribution in independent cohorts from the UK and South Africa, to identify associated host characteristics, and to compare with VL in HIV-1 and hepatitis ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0002-4036-4269
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
ORCID:
0000-0002-7089-7680
Publisher:
F1000Research
Journal:
Wellcome Open Research More from this journal
Volume:
5
Issue:
113
Publication date:
2020-06-01
Acceptance date:
2020-10-14
DOI:
Language:
English
Keywords:
Pubs id:
1082283
Local pid:
pubs:1082283
Deposit date:
2020-06-22

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