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Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

Abstract:

Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required for centriole assembly, but it is unclear how mutations in them lead to microcephaly. We show that the TCP domain of CPAP constitutes a novel proline recognition domain that forms a 1:1 complex with a short, highly conserved target motif in S...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.01071

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2013
Issue:
2
Article number:
e01071
Publication date:
2013-09-17
Acceptance date:
2013-07-30
DOI:
EISSN:
2050-084X
Source identifiers:
429296
Language:
English
Keywords:
Pubs id:
pubs:429296
UUID:
uuid:efb41442-039f-4fae-ab78-cc9714ef3c1e
Local pid:
pubs:429296
Deposit date:
2013-11-16

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