Journal article
Bias of selection on human copy-number variants
- Abstract:
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Although large-scale copy-number variation is an important contributor to conspecific genomic diversity, whether these variants frequently contribute to human phenotype differences remains unknown. If they have few functional consequences, then copy-number variants (CNVs) might be expected both to be distributed uniformly throughout the human genome and to encode genes that are characteristic of the genome as a whole. We find that human CNVs are significantly overrepresented close to telomere...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 894.4KB)
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- Publisher copy:
- 10.1371/journal.pgen.0020020
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Authors
Contributors
+ Trask, B
Institution:
Fred Hutchinson Cancer Research Center, USA
Role:
Editor
Funding
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 2
- Issue:
- 2
- Article number:
- e20
- Publication date:
- 2006-02-01
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:efc9cd98-e433-423c-b626-f98e4a3aa54f
- Local pid:
- ora:988
- Deposit date:
- 2008-03-14
Related Items
Terms of use
- Copyright holder:
- Nguyen, DQ et al
- Copyright date:
- 2006
- Notes:
-
Citation: Nguyen, D-Q., Webber C., Ponting C. P. (2006) Bias of selection on human copy-number variants. PLoS Genetics 2(2): e20. [Available at http://genetics.plosjournals.org/perlserv/?request=index-html&issn=1553-7404].
Copyright: © 2006 Nguyen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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