Bias of selection on human copy-number variants
Although large-scale copy-number variation is an important contributor to conspecific genomic diversity, whether these variants frequently contribute to human phenotype differences remains unknown. If they have few functional consequences, then copy-number variants (CNVs) might be expected both to be distributed uniformly throughout the human genome and to encode genes that are characteristic of the genome as a whole. We find that human CNVs are significantly overrepresented close to telomere...Expand abstract
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Citation: Nguyen, D-Q., Webber C., Ponting C. P. (2006) Bias of selection on human copy-number variants. PLoS Genetics 2(2): e20. [Available at http://genetics.plosjournals.org/perlserv/?request=index-html&issn=1553-7404].
Copyright: © 2006 Nguyen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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