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Thesis

Cell fate mechanisms in colorectal cancer

Abstract:

Colorectal cancer (CRC) arises in part from the dysregulation of cellular proliferation, associated with the canonical Wnt pathway, and differentiation, effected by the Notch signalling network. In this thesis, we develop a mathematical model of ordinary differential equations (ODEs) for the coupled interaction of the Notch and Wnt pathways in cells of the human intestinal epithelium. Our central aim is to understand the role of such crosstalk in the genesis and treatment of CRC.

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Research group:
Computational Biology
Oxford college:
Keble College
Role:
Author

Contributors

Division:
MPLS
Department:
Computer Science
Role:
Supervisor
Division:
MPLS
Department:
Computer Science
Role:
Supervisor
Division:
MPLS
Department:
Computer Science
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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