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Journal article

Native functionality and therapeutic targeting of arenaviral glycoproteins

Abstract:

Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralising antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivira...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.coviro.2016.04.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More from this funder
Funding agency for:
Zeltina, A
Grant:
658363
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Funding agency for:
Zitzmann, N
Grant:
Personal consultancy
More from this funder
Funding agency for:
Bowden, T
Grant:
MR/J007897/1
MR/N002091/1
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Virology Journal website
Volume:
18
Pages:
70–75
Publication date:
2016-04-16
Acceptance date:
2016-04-04
DOI:
EISSN:
1879-6265
ISSN:
1879-6257
Source identifiers:
613759
Keywords:
Pubs id:
pubs:613759
UUID:
uuid:f19c2fab-ea7e-494d-ae87-507edd69ca9b
Local pid:
pubs:613759
Deposit date:
2016-04-05

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