Journal article
Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
- Abstract:
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Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of Mycobacterium tuberculosis (M.tb), presumably via nitric oxide (NO) mediated killing. Here we show that leukocyte-specific deficiency of NO production, through targeted loss of the iNOS cofactor tetrahydrobiopterin (BH4), results in enhanced control of M.tb infection; by contrast, loss of iNOS renders mice susceptible to M.tb. By comparing two complementary NO-deficient models, Nos2-/-mice and BH4 deficien...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 2.9MB)
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- Publisher copy:
- 10.1038/s41467-018-07714-9
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Authors
Funding
Oxford University Medical Research Fund
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John Fell Fund
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National Institute for Health Research
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Article number:
- 5409
- Publication date:
- 2018-12-20
- Acceptance date:
- 2018-11-21
- DOI:
- EISSN:
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2041-1723
Item Description
- Pubs id:
-
pubs:944838
- UUID:
-
uuid:f1bb7a8b-4b81-4223-bf96-14413e1080be
- Local pid:
- pubs:944838
- Deposit date:
- 2018-11-21
Terms of use
- Copyright holder:
- McNeill et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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