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Journal article

Correctors of mutant CFTR enhance subcortical cAMP/PKA signaling via ezrin phosphorylation and cytoskeleton organization

Abstract:

The most common mutation of Cystic Fibrosis (CF) Transmembrane Regulator (CFTR) gene, F508del, produces a misfolded protein resulting in its defective trafficking to the cell surface and an impaired chloride secretion. Pharmacological treatments partially rescue F508del CFTR activity either directly by interacting with the mutant protein and/or indirectly by altering the cellular protein homeostasis. We show that the ezrin phosphorylation together with its binding to phosphatidylinositol-4,5-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/jcs.177907

Authors


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Funding agency for:
Zaccolo, M
Grant:
PG/15/5/31110
RG/12/3/29423
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Grant:
RG/12/3/29423
PG/15/5/31110
Publisher:
Company of Biologists Ltd Publisher's website
Journal:
Journal of Cell Science Journal website
Publication date:
2016-01-01
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Source identifiers:
599424
Keywords:
Pubs id:
pubs:599424
UUID:
uuid:f1c08030-d035-415e-8f22-5f2a258357c0
Local pid:
pubs:599424
Deposit date:
2016-02-08

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