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Journal article : Review

Sweet melody or jazz? Transcription around DNA double-strand breaks

Abstract:

Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging factors. To preserve genome stability, cells developed comprehensive DNA damage response (DDR) pathways that mediate the recognition of damaged DNA lesions, the activation of signaling cascades, and the execution of DNA repair. Transcription has been understood to pose a threat to genome stability in the presence of DNA breaks. Interestingly, accumulating evidence in recent years shows that the tran...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fmolb.2021.655786

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Wadham College
Role:
Author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Molecular Biosciences Journal website
Volume:
8
Article number:
655786
Publication date:
2021-04-20
Acceptance date:
2021-03-22
DOI:
EISSN:
2296-889X
Pmid:
33959637
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1176719
Local pid:
pubs:1176719
Deposit date:
2022-01-24

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