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Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Abstract:

The non-classical class Ib molecule human leukocyte antigen E (HLA-E) has limited polymorphism and can bind HLA class Ia leader peptides (VL9). HLA-E-VL9 complexes interact with the natural killer (NK) cell receptors NKG2A-C/CD94 and regulate NK cell-mediated cytotoxicity. Here we report the isolation of 3H4, a murine HLA-E-VL9-specific IgM antibody that enhances killing of HLA-E-VL9-expressing cells by an NKG2A+ NK cell line. Structural analysis reveal that 3H4 acts by preventing CD94/NKG2A ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-022-03183-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0002-0587-7560
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Communications Biology Journal website
Volume:
5
Article number:
271
Publication date:
2022-03-28
Acceptance date:
2022-02-17
DOI:
EISSN:
2399-3642
Language:
English
Keywords:
Pubs id:
1240090
Local pid:
pubs:1240090
Deposit date:
2022-02-18

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