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Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank

Abstract:

Background Antibodies against the HPV16 oncoprotein E6 are promising biomarkers for HPV16-driven oropharyngeal cancer (HPV16-OPC) due to their high sensitivity and specificity, and prospective manifestation. In previous studies, 0•7% of controls without HPV-associated malignancies were HPV16 E6 seropositive of which only a minority is expected to develop HPV16-driven cancer. We aimed to characterise HPV16 E6 antibodies in individuals without HPV-associated malignancies. Methods We analysed s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2020.103123

Authors


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Institution:
University of Oxford
Division:
MSD
Sub department:
BX POPULATION HEALTH; CS BIG DATA INSTITUTE - NDPH
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-4502-2209
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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
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Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
62
Article number:
103123
Publication date:
2020-11-25
Acceptance date:
2020-10-28
DOI:
EISSN:
2352-3964
Pmid:
33248371
Language:
English
Keywords:
Pubs id:
1148373
Local pid:
pubs:1148373
Deposit date:
2021-06-02

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