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A randomised study comparing the safety and immunogenicity of a conjugate vaccine combination containing meningococcal group C and pneumococcal capsular polysaccharide - CRM197 with a meningococcal group C conjugate vaccine in healthy infants: challenge phase

Abstract:

Background: A combination nonavalent pneumococcal-group C meningococcal conjugate vaccine (Pnc9-MenC) was previously found to be safe and immunogenic when administered to infants at 2, 3 and 4 monts. This study describes the persistence of immunity at 12 months of age and the immunologic response to a challenge dose of either meningococcal polysaccharide vaccine (Meningivac A + C™; MnA + C), or MenC. Methods: A phase II, randomized, controlled trial of healthy infants. Subjects were given Pnc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Oxford Vaccine Group
Role:
Author
More by this author
Institution:
Public Health Laboratory, Health Protection Agency, Gloucestershire Royal Hospital, Gloucester, UK
Role:
Author
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Contributors

Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
25
Issue:
19
Pages:
3906-3912
Publication date:
2007-05-01
DOI:
ISSN:
0264-410X
Language:
English
Keywords:
Subjects:
UUID:
uuid:f23b3087-8878-4a6b-8431-7116d0016b17
Local pid:
ora:4200
Deposit date:
2010-09-22

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