Thesis
The effects of energetic substrate manipulation on myocardial metabolism and cardiac function
- Abstract:
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The healthy human heart uses fat and glucose as its predominant metabolic substrates, approximately in a ratio of 70% to 30%. In heart failure, substrate oxidation is decreased as is ATP production. Free fatty acid uptake and oxidation is reduced, while glucose uptake and glycolysis are increased, although pyruvate oxidation falls. This thesis set out to establish the links between myocardial substrate metabolism and function in the healthy and the failing human heart, at rest and at stres...
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Authors
Contributors
+ Rider, O
Role:
Supervisor
+ Herring, N
Role:
Supervisor
+ Neubauer, S
Role:
Supervisor
+ Evans, R
Role:
Examiner
+ Wiggers, H
Role:
Examiner
Funding
+ British Heart Foundation
More from this funder
Grant:
FS/17/48/32907
Funder identifier:
http://dx.doi.org/10.13039/501100000274
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-11-27
Related Items
Terms of use
- Copyright holder:
- Watson, WD
- Copyright date:
- 2021
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