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Thesis

The effects of energetic substrate manipulation on myocardial metabolism and cardiac function

Abstract:

The healthy human heart uses fat and glucose as its predominant metabolic substrates, approximately in a ratio of 70% to 30%. In heart failure, substrate oxidation is decreased as is ATP production. Free fatty acid uptake and oxidation is reduced, while glucose uptake and glycolysis are increased, although pyruvate oxidation falls. This thesis set out to establish the links between myocardial substrate metabolism and function in the healthy and the failing human heart, at rest and at stres...

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MSD
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Author

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Examiner
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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Deposit date:
2021-11-27

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