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Cytotoxic T-cell antagonism in HIV-1

Abstract:

The cytotoxic T-cell (CTL) response to human immunodeficiency virus Type 1 (HIV-1) is vigorous and sustained, but despite this, the virus persists. Natural variation arising within CTL epitopes may affect CTL recognition of infected targets and allow viral escape. Some of these variant epitopes appear to engage T-cell receptors but fail to activate the CTL normally. This can interfere with recognition of the unmutated epitope - a phenomenon known as T-cell antagonism. We discuss the evidence ...

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Publication status:
Published

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Publisher copy:
10.1006/smvy.1996.0005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
SEMINARS IN VIROLOGY
Volume:
7
Issue:
1
Pages:
31-39
Publication date:
1996-02-01
DOI:
ISSN:
1044-5773
Source identifiers:
18852
Language:
English
Keywords:
Pubs id:
pubs:18852
UUID:
uuid:f2892f70-d7bd-4cae-b5bb-8e336678f95b
Local pid:
pubs:18852
Deposit date:
2012-12-19

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