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Journal article

Synergy between variant PRC1 complexes defines polycomb-mediated gene repression

Abstract:

The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic. Here, we use combinatorial genetic perturbation coupled with quantitative genomics to discover the central determinants of Polycomb-mediated gene repression in mouse embryonic stem cells. We demonstrate that canonical Polycomb repressive complex ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2019.03.024

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
74
Issue:
5
Pages:
1020-1036.e8
Publication date:
2019-04-24
Acceptance date:
2019-03-21
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Pmid:
31029541
Language:
English
Keywords:
Pubs id:
pubs:987655
UUID:
uuid:f2c4fda5-2c62-40e6-a93d-fbe416977f5c
Local pid:
pubs:987655
Deposit date:
2019-04-08

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