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Journal article

Down syndrome preleukemia and leukemia.

Abstract:

Children with Down syndrome (DS) and acute leukemias acute have unique biological, cytogenetic, and intrinsic factors that affect their treatment and outcome. Myeloid leukemia of Down syndrome (ML-DS) is associated with high event-free survival (EFS) rates and frequently preceded by a preleukemia condition, the transient abnormal hematopoiesis (TAM) present at birth. For acute lymphoblastic leukemia (ALL), their EFS and overall survival are poorer than non-DS ALL, it is important to enroll th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.pcl.2014.09.009

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Pediatric Clinics of North America Journal website
Volume:
62
Issue:
1
Pages:
121-137
Publication date:
2014-11-28
DOI:
EISSN:
1557-8240
ISSN:
0031-3955
Source identifiers:
493463
Language:
English
Keywords:
Pubs id:
pubs:493463
UUID:
uuid:f2ce4a84-b6f2-403c-ae90-bfbc7e3e4edb
Local pid:
pubs:493463
Deposit date:
2015-01-06

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