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Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer

Abstract:

Background

Glutamine (Gln) is an abundant nutrient used by cancer cells. Breast cancers cells and particularly triple-receptor negative breast cancer (TNBC) are reported to be dependent on Gln to produce the energy required for survival and proliferation. Despite intense research on the role of the intracellular Gln pathway, few reports have focussed on Gln transporters in breast cancer and TNBC.

Methods

The role and localisation of the Gln tra... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-020-01113-y

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Publisher:
Springer Nature Publisher's website
Volume:
124
Pages:
494–505
Series:
British Journal of Cancer
Publication date:
2020-10-08
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Pubs id:
1110778
Local pid:
pubs:1110778
Deposit date:
2020-06-08

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