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Journal article

Control of intestinal inflammation by regulatory T cells.

Abstract:

Transfer of CD4+ T cells to immune-deficient mice in the absence of the CD25+ subset leads to the development of colitis, indicating that regulatory cells capable of controlling a bacteria-driven inflammatory response are present in normal mice. Cells with this function are present in the thymus as well as in the periphery of germ-free mice, suggesting they may be reactive with self-antigen. These cells resemble CD4+CD25+ cells that inhibit organ-specific autoimmunity, suggesting that a simil...

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Publication status:
Published

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Journal:
Immunological reviews
Volume:
182
Issue:
1
Pages:
190-200
Publication date:
2001-08-01
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
Source identifiers:
28927

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