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Overcoming monocarboxylate transporter 8 (MCT8)-deficiency to promote human oligodendrocyte differentiation and myelination

Abstract:

Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits oligodendrogenesis and myelination. We show that human oligodendrocytes (OL), derived from the NKX...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2017.10.016

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Role:
Author
ORCID:
0000-0002-0390-3454
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Role:
Author
ORCID:
0000-0003-3885-8777
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Multiple Sclerosis Research Australia More from this funder
National Multiple Sclerosis Society More from this funder
NeuOrphan P/L commercial agreement More from this funder
Trish MS Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
25
Pages:
122-135
Publication date:
2017-10-19
Acceptance date:
2017-10-16
DOI:
EISSN:
2352-3964
ISSN:
2352-3964
Pmid:
29111262
Source identifiers:
896305

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