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Thesis

Characterization of non-apoptotic roles of Dronc (Caspase-2/9) as a tumor Suppressor in Drosophila wound-like tumors

Abstract:

Caspases are proteases best known for their ability to carry out the process of programmed cell death known as apoptosis. Through this function, caspases can act as tumor suppressors, and the evasion of apoptosis and cell death is an established hallmark of cancer. However, caspase activity has also been shown to be involved in a plethora of non-apoptotic physiological processes, and when deregulated, can also contribute to many other aspects of tumor initiation and progression. Because ca...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0003-3446-0331

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
ORCID:
0000-0002-8663-3794
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Examiner
ORCID:
0000-0003-0410-5451
Institution:
University of Copenhagen
Role:
Examiner
More from this funder
Programme:
National Institutes of Health Oxford-Cambridge Scholars Program
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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