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Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size

Abstract:

Recently reported DNA nanoflowers are an interesting class of organic-inorganic hybrid materials which are prepared using DNA polymerases. DNA nanoflowers combine the high surface area and scaffolding of inorganic Mg2P2O7 nanocrystals with the targeting properties of DNA, whilst adding enzymatic stability and enhanced cellular uptake. We have investigated conditions for chemically modifying the inorganic core of these nanoflowers through substitution of Mg2+ with Mn2+, Co2+ or Zn2+ and have c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gky630

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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Chemistry; Organic Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Chemistry; Chemical Biology
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Physics; Condensed Matter Physics
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Chemistry; Organic Chemistry
Role:
Author
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Funding agency for:
Brown, T
Grant:
B/J001694/2
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Funding agency for:
El-Sagheer, AH
Grant:
B/J001694/2
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
2018
Issue:
1
Publication date:
2018-07-12
Acceptance date:
2018-06-29
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
30010979
Source identifiers:
891313
Language:
English
Keywords:
Pubs id:
pubs:891313
UUID:
uuid:f541104d-7534-48f9-ade6-2165d4740c65
Local pid:
pubs:891313
Deposit date:
2018-08-10

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