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Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package

Version:
3

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Creator, Principal Investigator (PI)

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Researcher
Expand contributors...
Publisher:
University of Oxford
Publication date:
2018
Version number:
3
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe propert... Expand documentation
UUID:
uuid:f56da83b-dd1a-490a-80b2-5d668481c38b
Deposit date:
2018-05-08

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