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Efficacy of B-type natriuretic peptide is coupled to phosphodiesterase 2A in cardiac sympathetic neurons

Abstract:

Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevation is regarded as an early compensatory response to cardiac failure where it can facilitate sympathovagal balance and cardiorenal homeostasis. However, recent reports suggest a paradoxical proadrenergic action of BNP. Because phosphodiesterase activity is altered in cardiovascular disease, we tested the hypothesis that BNP might lose its efficacy by minimizing the action of cGMP on downstream pathw...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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British Heart Foundation More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
66
Issue:
1
Pages:
190-198
Publication date:
2015-01-01
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Source identifiers:
521487

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