Familial tendency to foetal loss analysed with Bayesian graphical models by Gibbs sampling.

Journal article

This paper presents several models for investigating whether the HLA allogenotypes DR1/Br, DR3 and DR10 are genetic markers for a predisposition of experiencing unexplained recurrent foetal losses. A total of 199 women from 113 families answered questionnaires concerning their pregnancies and 145 of these women were HLA typed. The analysis of the data is complicated as dependencies between pregnancy outcomes are expected. The main purpose of the paper is to illustrate how such analyses can be...

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Authors: Hundborg, H; Hojbjerre, M; Bjarne Christiansen, O; Lauritzen, S

• Publication status: Published
• Journal: Statistics in medicine
• Volume: 19
• Issue: 16
• Pages: 2147-2168
• Publication date: 2000-08-01
• DOI: 10.1002/1097-0258(20000830)19:16<2147::aid-sim498>3.0.co;2-c
• EISSN: 1097-0258
• ISSN: 0277-6715
• Language: English
• Keywords: Models, Statistical; Markov Chains; Adult; Infant, Newborn; Bayes Theorem; Genetic Predisposition to Disease; Likelihood Functions; Abortion, Habitual; Alleles; Odds Ratio; Statistical Distributions; HLA Antigens; Humans; HLA-DR Antigens; Pregnancy Outcome; Questionnaires; Monte Carlo Method; Pregnancy; Genetic Markers; Female